Table 1 The cysteine residues and the disulfide bonds in PAPP-A complexes.
From: Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2
Protein | Domain | Cysteine pairing | |||
|---|---|---|---|---|---|
PAPP-A | LGD | ||||
PD (LNR1–2) | C247–C507 | C252–C577 | C334–C348 | C344–C360 | |
C377–C393 | C381–C51PM | C394–C405 | C503–C542 | ||
C520-unpaired | C532–C563 |  |  | ||
SD | C630–C801 | C633–C798 | C652–C169PM/C120ST |  | |
C673–C755 | C695–C701 |  |  | ||
βBD | C867–C895 | C880–C891 | C903–C910 | C919–C931 | |
C956–C990 | C971–C1059 | C1112–C1125 | C1130–C1130 | ||
CCP1–5 | C1135–C1189 | C1147–C1158 | C1162–C1200 | C1205–C1249 | |
C1220–C1230 | C1234–C1262 | C1266–C1319 | C1282–C1293 | ||
C1297–C1330 | C1335–C1378 | C1348–C1358 | C1362–C1391 | ||
C1398–C1459 | C1412–C1422 | C1426–C1474 |  | ||
CTD (LNR3) | C1478–C1496 | C1487–C1503 | C1504–C1528 | C1520–C1526 | |
proMBP | – | C51–C381PA | C89–C128 | C104–C107 | C125–C220 |
C147-unpaired | C169–C652PA | C197–C212 | C201-unpaired | ||
STC2 | – | C56–C70 | C65–C85 | C76–C125 | C109–C139 |
C120–C652PA | C146–C181 | C197–C205 | C211–C211 | ||
