Fig. 7: PD-L1 K263 deacetylation facilitates angiogenesis and tumorigenesis in vivo.
From: Nuclear PD-L1 promotes EGR1-mediated angiogenesis and accelerates tumorigenesis
a Representative bioluminescent images of UM orthotopic xenografts. b Statistical analysis of the bioluminescent signals in UM orthotopic xenografts. n = 5. c Statistical analysis of the tumor weight. n = 5. Data are presented as means ± SD. Two-tailed unpaired Student’s t-test. d Representative images of H&E staining of UM orthotopic xenografts generated by tumor cells with indicated constructs. e IF images of CD31 in UM orthotopic xenografts generated by tumor cells with indicated constructs. Scale bars, 40 µm. f Statistical analysis of CD31 expression in UM orthotopic xenografts. n = 5. Data are presented as means ± SD. Two-tailed unpaired Student’s t-test. g Representative bioluminescent images of UM orthotopic xenografts generated by tumor cells with indicated constructs and treated with HDAC2i. h Statistical analysis of the bioluminescent signals in UM orthotopic xenografts. n = 5. i Statistical analysis of the tumor weight. n = 5. Data are presented as means ± SD. Two-tailed unpaired Student’s t-test. j Representative images of H&E staining of UM orthotopic xenografts generated by tumor cells with indicated constructs and treated with HDAC2i. k IF images of CD31 in UM orthotopic xenografts generated by tumor cells with indicated constructs and treated with HDAC2i. Scale bars, 40 µm. l Statistical analysis of CD31 expression in UM orthotopic xenografts. n = 5. Data are presented as means ± SD. Two-tailed unpaired Student’s t-test.
