Fig. 3: Mesen_CAF was prominent in OSCC initiation. | Cell Discovery

Fig. 3: Mesen_CAF was prominent in OSCC initiation.

From: Single-cell and spatial dissection of precancerous lesions underlying the initiation process of oral squamous cell carcinoma

Fig. 3

a UMAP plots showing the subpopulations of fibroblasts. b Violin plot showing seven representative marker genes expressions of Mesen_CAFs and Infla_CAFs. c UMAP feature plots showing expression distribution of cancer-associated fibroblast cell markers FAP and PDGFRA in single fibroblast cells. d Violin plot showing gene-expression levels of pan-CAF markers in two fibroblasts’ subpopulations. e Spatial feature plots of Mesen_CAFs markers (WNT5A and TNC) and Infla_CAFs markers (IGF1 and CXCL12) in tissue sections of P6. f Statistical results showing proportions of (WNT5A, TNC, IGF1 and CXCL12) positive points in different tissue regions by ST analyses. A two-tailed unpaired Student’s t-test for the P values. **P < 0.01. ***P < 0.001. g Statistics for scoring the positive points of CXCL12–CXCR4 and WNT5a–FZD6 interactions in 5 representative spatial feature plots. h Enriched Hallmark gene sets in Mesen_CAFs and Infla_CAFs with QuSAGE.

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