Fig. 1: Antibody landscape of the structure available antibodies against SARS-CoV-2 S protein.

a Distribution of the antibody number in the available structures. The antibody and corresponding binding domain are extracted as a subcomplex. Most structures contain only one antibody. b Strain distribution of the S protein in subcomplexes. Most of the S proteins are WT. c Statistics of ordinary antibodies and nanobodies and their corresponding targeting domains in the S protein. d Cluster distribution of the 10 classes of ordinary antibodies targeting RBD, named Ab-A-RBD to Ab-J-RBD, where Ab represents antibody and can be omitted as A-RBD to J-RBD without causing confusion, and structural scheme of the structural classes of some representative RBD antibodies. e is the same as d for 4 classes of NTD antibodies (named Ab-A-NTD to Ab-D-NTD, where Ab represents antibody and can be omitted as A-NTD to D-NTD without causing confusion). f is the same as d for the 5 classes of RBD nanobodies. For the t-SNE analysis of NTD antibodies, all of subcomplexes were used for analysis. For RBD antibodies, only the representative subcomplexes were used. g Epitope distributions of 10 classes of ordinary antibodies targeting RBD. The color depth represents the frequency of the residues as epitopes. The PDB ID for RBD of the S protein is 7QUS.