Fig. 3: Binding and neutralization activities of the potential broad-spectrum antibodies.
a Heatmap showing the binding EC50 against S fragments of SARS-CoV-2 variants and neutralization IC50 of pseudotyped SARS-CoV-2 variants. b The average binding EC50 against the WT, Delta, and the five indicated Omicron variants, and the average number of epitope residues mutated in Omicron (ANERMO) of different classes of antibodies. c The average neutralization IC50 against the WT, Delta, and the five indicated Omicron variants, and the ANERMO of different classes of antibodies. d The Pearson correlation coefficients analysis between the average binding EC50 and the average neutralization IC50 values of the expressed antibodies. e The average binding EC50 fold change between the five indicated Omicron variants and WT, and the ANERMO of different classes of antibodies. f The average neutralization IC50 fold change between the five indicated Omicron variants and WT, and the ANERMO of different classes of antibodies. g The Pearson correlation coefficients analysis between the average binding EC50 fold change and the ANERMO of the expressed antibodies. Samples were tested in triplicate. Data are shown as mean ± SD. h The neutralization activities of antibodies from H-RBD class against pseudotyped XBB and XBB.1.5 variants.
