Fig. 5: Using ZXH-3-26 to explore whether BRD4 is a key driver in condensates. | Cell Discovery

Fig. 5: Using ZXH-3-26 to explore whether BRD4 is a key driver in condensates.

From: BRD4-targeting PROTAC as a unique tool to study biomolecular condensates

Fig. 5

a The network of BRD4 protein interaction. b Heat map of changes in the number of BRD4, CYCT1, MED1, and p300 condensates after ZXH-3-26 (100 nM) or JQ1 (500 nM) treatment for different times, n = 25–30 cells per time point. Z score was normalized by the formula, Z score = (X–mean)/SD, X was condensate number. c Western blotting of p300 in HeLa cells treated with different concentrations of dCBP-1 for 6 h. d Changes in the number of p300 or BRD4 condensates after dCBP-1 (1 μM) treatment for 6 h, n = 25–30 cells per point.

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