Fig. 2: Trajectory inference and EGL progenitor subtypes in the GC lineage. | Cell Discovery

Fig. 2: Trajectory inference and EGL progenitor subtypes in the GC lineage.

From: Single-cell multi-omics analysis of lineage development and spatial organization in the human fetal cerebellum

Fig. 2

a Visualization of GC lineages in different phases of cell cycle (top). Pseudotime trajectory visualized on UMAP embedding of G1 phase GC progenitors and postmitotic GCs (bottom). Blue, orange and pink arrows mark three potential sublineages suggested by the trajectory. b Altered expression patterns of different genes along the pseudotime. An overview (left) and the detailed patterns of several genes (right). c Visualization of the AT+GCP and ND+GCP (left) and violin plot showing the expression patterns of their marker genes (right). d Spatial gene expression patterns showing the separated expressions of ATOH1 and NEUROD1 in both GW13 and GW16 EGL in human cerebellum. e Enrichment plots of GO and KEGG terms in AT+GCP compared with ND+GCP. f GRNs of GC development. g Gene expression patterns of SFRP1 and PRPH in scRNA-seq and spatial RNA-seq data. h Spatial gene expression patterns of CPLX3 and SV2B at GW16 with arrowheads highlighting the enrichment in the EGL (left). Protein interaction network according to STRING (right).

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