Fig. 4: UBC progenitors and GRN of UBC sublineages.

a Visualization of the UBC lineages. UBCpro-3cc was short for S/G2/M phase UBCpro-3. b Dot plot showing the expression patterns of marker genes of different cell types in a. Genes used in the following illustration of the compartmentation of the RL are colored bule. c Heatmap showing the high strength of co-expressed gene module containing EOMES and CALCB in URL (left). The RNA count map and fluorescence image of human GW16 cerebellum with URL marked by arrowheads (right). d Spatial gene expression patterns showing the distribution of COL2A1⁺ cells in URL, while CALCB⁺ and EOMES⁺ cells established the VZ and SVZ of URL in both GW13 and GW16 human cerebellums. e Heatmap showing the scaled regulon strength in different UBC progenitors. f Gene expression patterns of CNTNAP5 and LMX1A in different UBC sublineages (left). Gene expression patterns of the reported markers for UBC sublineages (right). g Heatmap showing the correlation coefficients of marker genes for UBC sublineages. h GRN showing the potential regulatory programs of different UBC sublineages.