Fig. 2: Immunological aspects of Parkinson’s disease. | Cell Discovery

Fig. 2: Immunological aspects of Parkinson’s disease.

From: Immunological aspects of central neurodegeneration

Fig. 2

Patients with Parkinson’s disease (PD) exhibit synuclein alpha (SNCA)-related microglial activation coupled with the initiation of multiple signalling pathways that result in the abundant secretion of pro-inflammatory cytokines in the cerebrospinal fluid (CSF). Such cytokines promote the recruitment of immune cells that contribute to neuroinflammation by secreting proinflammatory mediators such as interferon gamma (IFNG). BBB blood brain barrier, IL interleukin, TNF tumor necrosis factor, TREG regulatory T. Created with BioRender.com.

Back to article page