Fig. 3: Cryo-EM reconstruction of the complex of MCX-190 and WT ribosomes of S. aureus. | Cell Discovery

Fig. 3: Cryo-EM reconstruction of the complex of MCX-190 and WT ribosomes of S. aureus.

From: Synthetic macrolides overcoming MLSBK-resistant pathogens

Fig. 3

a The overall and detail of MCX-190 bound to the NPET. The distance of the hydrogen bond between the 2’-OH of desosamine and N1 positions of A2058 (A2085) is 2.93 Å. b The density map of MCX-190 and cation Mg2+ in the WT ribosome complex. c Cation Mg2+ is chelated by the quinolone element and the other four H2O molecules. d A cyclopropyl group at the N1 position of quinolone could create steric clashes with U2609 (U2636).

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