Fig. 5: Cytotoxicity and inhibition of eukaryotic translation by MCX-219 and MCX-190. | Cell Discovery

Fig. 5: Cytotoxicity and inhibition of eukaryotic translation by MCX-219 and MCX-190.

From: Synthetic macrolides overcoming MLSBK-resistant pathogens

Fig. 5

a Cytotoxicity of the optimal compounds at a concentration of 5 μM with an incubation for 48 h. b, c Cell viability of HepG2 (b) and HEK293T (c) cells in the presence of increasing concentrations of MCX-219 or MCX-190. MCX-219 showed a calculated cytotoxicity concentration at 26 μM that inhibits 50% viability (CC50), while TcmX reportedly had a CC50 of 2 μM (c). d In vitro translation of Fluc mRNA in HEK293F whole-cell lysate in increasing concentrations of MCX-219 or MCX-190. CHX cycloheximide. Values are shown as the mean ± SD of at least three independent experiments.

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