Fig. 4: Enriched biological processes based on DSP profiles in different pathological regions of SCLC.

a Enriched biological processes of tumor nest and tumor stroma ROIs. b The expression of CD20 protein in tumor nest (green), tumor stroma (orange), and para-tumor (blue) ROIs. c The protein levels in tumor stroma (y axis) and tumor nest (x axis) respectively associated with OS of 44 LS-SCLC patients. Red dots: proteins significantly (P < 0.05) associated with longer survival. Blue dots: proteins significantly (P < 0.05) associated with longer survival. The log-rank test was used for the survival analysis, and patients were stratified by the median level of each protein.