Fig. 7: The innate immune response in TIME of SCLC. | Cell Discovery

Fig. 7: The innate immune response in TIME of SCLC.

From: Single-cell and spatial proteo-transcriptomic profiling reveals immune infiltration heterogeneity associated with neuroendocrine features in small cell lung cancer

Fig. 7

a The communication scores for each LR and cell pair. The lighter red color patches represent stronger interactions between sender and receiver cells. b CCI scores of each cell type pair based on the curated list of LR pairs. Agglomerative hierarchical clustering was performed on a dissimilarity-like metric by taking the complement (1-score) of CCI scores, disregarding autocrine interactions. Cell types are colored by their lineages, as indicated in the legend. c Heatmap showing the mean spot factor of the immune cell portion identified by the cell2location algorithm. d The abundance of major immune subsets in different spatial locations. Significance was assessed using the rank-sum test. e The abundance of major immune subsets in LUAD and SCLC. f Histogram showing the immune cell portion of SCLC and LUAD bulk RNA-seq identfied by cell-type deconvolution. The proportion of CD8+ Texh, Mono/Marco, B cells, and neutrophils in LUAD (left) vs SCLC (right). g UMAP plots showing expression of TRGC2 and CD163 in T cell subsets and macrophages, respectively. Plots represent para-tumor normal samples vs tumors and expression levels are shown in scaled on the right.

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