Fig. 3: Med23 ablation impairs remyelination capacity in the LPC injury mouse model. | Cell Discovery

Fig. 3: Med23 ablation impairs remyelination capacity in the LPC injury mouse model.

From: Mediator MED23 controls oligodendrogenesis and myelination by modulating Sp1/P300-directed gene programs

Fig. 3

a Diagram showing the LPC injection schedule. b In situ hybridization for Pdgfra and Plp1 in spinal cord lesions from P60 Ctrl and Med23cKO mice at dpl 7 and dpl 14. Scale bars: 50 μm. c, d Quantification of the number of Pdgfra+ OPCs (c) and mature Plp1+ OLs (d) in spinal cord lesions from P60 Ctrl and Med23cKO mice at 7 and 14 dpl. The data are presented as the mean ± SEM; n = 3 animals/genotype. Two-tailed unpaired Student’s t-test, ***P < 0.001.

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