Fig. 4: Genetic ablation of Grina in vHPC leads to reduced social competitiveness through remodeling of neural dynamics.

a The cumulative time of food occupation during the 6-min food competition task in Con and cKO mice (**P < 0.01 and ***P < 0.001, n = 5 for each group). b Left, in the food competition task, the winning rate of mice in each bout of scramble during competition task (P < 0.01, n = 5 for each group). Right, total food occupancy time of mice in the food competition task (P < 0.01, n = 5 for each group). c The UMAP plot of video clips color-coded by behavioral classification in Con round (Con mice as challengers) and cKO round (cKO mice as challengers) during a representative food competition trial. d Percentage of frames that correspond to a specific behavioral class out of the total frames in Con round and cKO round, n = 5 for each group. e The duration and frequency of specific behavioral class in Con and cKO round. Snatch duration, P = 0.0017; Snatch events, P = 0.0331; Retreat duration, P = 0.1013; Retreat events, P = 0.0097; n = 5 mice. f Left, the rotational population trajectories in neural state space of Con mouse 1 vHPC neurons during competition episodes. The trajectories are color-coded to correspond with distinct behavioral categories observed in the recorded mice. Green flow field: state 1; Red flow field: state 2; Blue flow field: state 3. Right, the corresponding sequential activity of vHPC neurons during competition episodes. g Same as f but cKO mice 1. h Dynamic velocity of Con and cKO mice in different discrete states. The dynamic velocity of state 1 was used as a baseline (***P < 0.001, *P < 0.05, n = 5 mice). i Scatter plot for attractor stability score vs line attractor score of state 3 separates Con and cKO mice.