Fig. 5: Restoration of vHPC Grina effectively elevates the social competitiveness in HL mice.

a A diagram of the experimental flowchart. Neuronal and behavioral evaluations were performed after the administration of TMX. TMX was administered via intraperitoneal injection (i.p.). b A representative fluorescence image showing the expression of Grina in vHPC neurons following TMX-injection. c The cumulative time of food occupancy during the food competition trials of the vehicle-i.p. (Con) and TMX-i.p. mice at day 7 (*P < 0.05, n = 5 for each group). d Left, the winning rate of mice in each bout of scramble during competition task at day 7 (P < 0.05, n = 5 for each group). Right, total food occupancy time of mice in the food competition task at day 7 (P < 0.05, n = 5 for each group). e Percentage of frames that correspond to specific behavioral class out of the total frames that in Con round (Con mice as challengers) and TMX round (TMX mice as challengers) at day 7, n = 5 for each group. f, g Continuous changes in dynamic velocity in state 2 (f) and snatch duration (g) after TMX or Con (vehicle) administration (n = 5 for each group). h The cross-correlation between changes in competitive behavior (snatch duration) and changes in neural representations (state 2 dynamic velocities). Red, TMX; Gray, vehicle. i–k Same as f–h, but for dynamic velocity in state 3 and retreat events.