Fig. 4: Structural analysis of caspase pro-domain and interactions with its partners. | Cell Discovery

Fig. 4: Structural analysis of caspase pro-domain and interactions with its partners.

From: Caspases: structural and molecular mechanisms and functions in cell death, innate immunity, and disease

Fig. 4

a Illustration of ASC:caspase-1 CARD octamer complex structure (PDB ID: 7KEU); ASC is shown in yellow, and caspase-1 in gray. b Representation of the caspase-1 CARD filament (PDB ID: 5FNA); each individual monomer unit of caspase-1 CARD is represented by a different color for clarity. c Illustration of the three common types of interactions between tadem DED (tDED) or CARD monomers of the caspases. d Structural representation of caspase-8 tDED filament (PDB ID: 5L08); the individual monomer tDED molecules are colored in pink and cornflower blue, respectively, to indicate the formation of the tDED filament.

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