Fig. 4: The structure of AGLType A in complex with FabGC1102 and FabHBC. | Cell Discovery

Fig. 4: The structure of AGLType A in complex with FabGC1102 and FabHBC.

From: Structural polymorphism of the antigenic loop in HBV surface antigen dictates binding of diverse neutralizing antibodies

Fig. 4

a Side view of the cryo-EM map of the HBsAg–FabGC1102–FabHBC complex. FabGC1102-VH and FabGC1102-VL are colored in purple and light purple, respectively, and others are colored the same in Fig. 2a. The approximate boundaries of the outer leaflet of the viral envelope are indicated as dashed lines. b A 180°-rotated side view of a. c Atomic model of the HBsAg-FabGC1102-FabHBC complex is shown as cartoons in the same colors as in (b). Locations of interactions between FabGC1102 and HBsAg are indicated with dashed boxes. d A 90°-rotated top view of a. e Close-up view of the interface between FabGC1102-VH and HBsAg boxed in (c). Key residues for the binding between FabGC1102-VH and HBsAg are shown as sticks. f Close-up view of the interface between FabGC1102 and HBsAg H2-β1 loop boxed in (c). Key residues for the binding between FabGC1102 and HBsAg H2-β1 loop are shown as sticks.

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