Fig. 7: Differences in the co-localization of C1QC+ RTMs and CD4+ T cells between R and NR CRC patients revealed by spatial transcriptomics. | Cell Discovery

Fig. 7: Differences in the co-localization of C1QC+ RTMs and CD4+ T cells between R and NR CRC patients revealed by spatial transcriptomics.

From: Spatially resolved C1QC+ macrophage-CD4+ T cell niche in colorectal cancer microenvironment: implications for immunotherapy response

Fig. 7

a Schematic diagram of niche computation, H&E staining of each sample, and the spatial map of niches. The white dashed line in the H&E section separated the para tumor from the tumor, and the black dashed line separated the tumor from the necrotic region. b Co-localization analysis using the MISTy algorithm. Median importance of cell-type abundance in predicting the abundances of other cell types within a spot for MSI_R (top left), MSI_NR (top right), MSS_R (bottom left), and MSS_NR (bottom right). c Spatial feature plots showing signature scores for MSI_R, MSI_NR, MSS_R, and MSS_NR samples. d Violin plots illustrating the gene set scoring results for each niche in the MSI_R_1 sample.

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