Fig. 5: Differential AhR signalling in ADT-induced dormant cells and recurrent cells. | Cell Discovery

Fig. 5: Differential AhR signalling in ADT-induced dormant cells and recurrent cells.

From: AR to GR switch modulates differential TDO2-Kyn-AhR signalling to promote the survival and recurrence of treatment-induced dormant cells in prostate cancer

Fig. 5

a Transcription start state (TSS) average map and heatmap for CUT-Tag sequencing analysis. b CUT-Tag sequencing analysis was carried out on the transcription factor AhR in LNCaP cells, LNCaP+ADT cells and LNCaP-EnzR cells. After normalization, three sets of co-analyses and pairwise comparisons were performed to compare the intersection of genes with peaks greater than 100. c Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of 2214 differential AhR-regulated genes when the ADT-treated and LNCaP groups were compared. d Average map and heatmap of apoptosis-related gene sets. e The mRNA levels of AhR, CYP1A1, BCL6, SHC3 and KRAS were measured after siRNA interference of AhR in LNCaP+ADT cells. f KEGG enrichment analysis of 234 differentially expressed AhR-regulated genes from comparison of the LNCaP-EnzR and LNCaP groups. g The mRNA levels of CCND1, CREB3L2, NFKB1, CREB5, PPP2R3A, EDN1, HSPG2, REL, and ANAPC13 were measured after siRNA interference of AhR in LNCaP-EnzR cells. KEGG enrichment analysis tool: https://david.ncifcrf.gov/. *P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001.

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