Fig. 6: DMBT1 promotes liver metastasis of breast cancer. | Cell Discovery

Fig. 6: DMBT1 promotes liver metastasis of breast cancer.

From: Breast cancer induces CD62L+ Kupffer cells via DMBT1 to promote neutrophil extracellular trap formation and liver metastasis

Fig. 6

a–c In vivo BLI (a), ex vivo BLI (b) and NETosis (c) in livers of NOD-SCID mice treated with Clod after intrasplenic inoculation of MCF7 with or without DMBT1 overexpression. d–f In vivo BLI (d), ex vivo BLI (e) and NETosis (f) of NOD-SCID mice treated with GSK484 after intrasplenic inoculation of MCF7 with or without DMBT1 overexpression. g–j NETosis (g), CD62L+ KCs (h) and in vivo BLI (i) of livers, and survival (j) of nude mice after intrasplenic injection of LvM16 cells with DMBT1 knockdown. k, l Primary tumor growth (k) and liver metastasis (l) in C57BL/6 mice after orthotopic injection of AT3 cells with Dmbt1 knockdown. n = 3 or 4 (a, b), 3 (c, h, k, l), 7 (d, i, j), 4 (e, f, g) mice per group. P values were obtained by repeated measures two-way ANOVA (a, d, i, k), Log rank test (j) or two-tailed unpaired t-test (others). Scale bars, 50 μm. Data are shown as mean ± SEM (a, d, i, k) or mean ± SD (others).

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