Fig. 3: Less lymphocyte infiltration in the TME of LM than BM. | Cell Discovery

Fig. 3: Less lymphocyte infiltration in the TME of LM than BM.

From: Immunological and pathological characteristics of brain parenchymal and leptomeningeal metastases from non-small cell lung cancer

Fig. 3

a Comparison of T/NK cell clusters between BM and LM. b Comparison of the percentages of T/NK cell clusters between BM and LM. Cell percentages were calculated by dividing the number of each cell state by the total number of immune cells. Main cell differences between BM and LM were highlighted with yellow transparent background. c Comparison of UMAP visualization of B cell clusters between BM and LM, colored by cell clusters. Plasma cells were marked by grey dashed circles. d Cell percentage of B cell clusters between BM and LM. e A sketch of the differences in lymphocyte composition between BM and LM. f mIHC staining of selected marker genes in BM and LM. Scale bar: 50 μm. g Selected marker genes show a TLS-like structure in BM01. Scale bar: 50 μm. h Brain MRI images before, 1 month, and 40 months after surgery with tumor resection of BM01. i Representative Computed Tomography (CT) images before and after treatment with EGFR-TKI (Osimertinib) of BM01.

Back to article page