Fig. 1 | Cell Research

Fig. 1

From: Competing for enhancers: PVT1 fine-tunes MYC expression

Fig. 1

PVT1 promoter represses MYC transcription in cis. Top: In normal topology, a number of PVT1 intragenic enhancer elements preferentially interact with the PVT1 gene promoter and sustain expression of the non-coding transcript. Bottom: In malignant topology, caused by mutational, structural or epigenetic inactivation of the PVT1 promoter, intragenic enhancer elements instead interact with the adjacent MYC oncogene. This increases MYC expression imparting proliferative advantage to cancer cells

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