Fig. 3
Single-cell variance in chromatin accessibility and DNA methylation during mouse oocyte maturation. a Median variance in DNA methylation and chromatin accessibility among individual cells in different genomic elements at each stage. b Density plots show the relationship between the variance in chromatin accessibility (200 bp upstream and 100 bp downstream of the TSS) and the variance in DNA methylation (1 kb upstream and 0.5 kb downstream of the TSS) in single oocytes. Only 6,990 genes covered at all stages were used to plot the density. The plots were separated to four quadrants: q1 indicates genes with high variance in both chromatin accessibility and DNA methylation; q2 indicates genes with high variance in chromatin accessibility but low variance in DNA methylation; q3 indicates genes with low variance in both chromatin accessibility and DNA methylation; q4 indicates genes with low variance in chromatin accessibility but high variance in DNA methylation. c Alluvial map showing the dynamics of genes in quadrants defined in Fig. 2b during mouse oocyte growth. Bars denote the number of genes in each quadrant at each stage, and lines between bars denote the number of genes transition from a certain quadrant at earlier stage to another quadrant at later stage. d Relationship among the chromatin accessibility (200 bp upstream and 100 bp downstream of the TSS), DNA methylation (1 kb upstream and 0.5 kb downstream of the TSS) of promoters and the expression of the corresponding genes. Genes on the x-axis were ranked by the gene expression level
