Fig. 4
From: Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing
Different features and origins of the early and late HECs. a UMAP showing early endothelial and hematopoietic populations in CS 10–11 of human embryos. Early HEC lies more closely to endothelial cell populations. b Expression patterns of typical endothelial and hematopoietic genes in early populations (CS 10 and CS 11). c Heatmap showing the average expressions of top 5 DEGs enriched in distinct populations. d The expression of top 10 DEGs in early and late HEC. e GO:BP terms (left) and pathways (right) enriched in early HEC (upper) and late HEC (lower). f UMAP of endothelial and hematopoietic cells from early (CS 10 and CS 11) and late (CS 13) stages with different populations mapped on it. Two distinct HEC clusters at high magnification are shown to the lower right. The distribution of two HEC clusters and endothelial (EC) and hematopoietic (HC) populations on UMAP is shown as schematic to the upper right. g UMAP with the expressions of indicated genes mapped on it
