Fig. 1
From: ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer
Identification of ILF3 as a poor prognosis marker in CRC. a Principal component analysis of microarrays from three paired CRC and normal tissue samples. PC1 and PC2 explain 66.79% and 18.99% of the variation, respectively. b Volcano plot analysis of different gene expressions after knockdown of ILF3 (P < 0.05, ∣fold change∣ > 3). c Heatmap of the top 50 genes that were upregulated in CRC. The color scale indicates a log2 ratio of the normalized hybridization signal intensities of the upregulated genes. d Waterfall plot of the relative ILF3 mRNA levels from 34 paired samples of CRC and normal tissue measured using qRT-PCR. e Expression of ILF3 in 79 paired normal and CRC tissue samples. f Representative images of ILF3 IHC staining in human colon cancer and adjacent normal colon tissue. Scale bars, 50 μm. g–i Kaplan–Meier survival curves based on ILF3 expression in the CRC tissues of the testing and validation cohorts. The receiver operating characteristic curve was used to define the cutoff, and log-rank analysis was used to test for significance.
