Fig. 5: NFE2L2 in ferroptosis.
From: Ferroptosis: molecular mechanisms and health implications
a Under normal conditions, a low level of NFE2L2 is primarily maintained by KEAP1-mediated proteasomal degradation. b Following ferroptosis stress, the NFE2L2 protein is stabilized and initiates a multi-step activation pathway, including nuclear translocation, heterodimerization with its partner MAF protein, recruitment of transcription coactivators and subsequent binding to the antioxidant response element (ARE) of the target gene promoter. SQSTM1 can stabilize NFE2L2 by inactivating KEAP1 through autophagic degradation.
