Fig. 7: Schematic diagram illustrating the dual role of cathD.
From: The noncanonical role of the protease cathepsin D as a cofilin phosphatase
In acidic organelles, mature cathD hydrolyzes protein and peptide substrates as a canonical protease (left). In neutral pH environments, immature cathD precursor acts as a noncanonical phosphatase to dephosphorylate p-cofilin and modulate cofilin-mediated processes such as actin remodeling and cell mitosis (right).
