Fig. 6: Neutrophil, dendritic cell and B-cell phenotypes in COVID-19 BAL.

a Subclustering of neutrophils into 5 phenotypes, as indicated by the color-coded legend. b UMAP showing expression of a marker gene for each neutrophil phenotype. c Heatmap showing neutrophil phenotypes with corresponding marker genes and functional gene sets. d Relative contribution of each neutrophil phenotype (in %) to COVID-19 vs non-COVID-19. e Relative contribution of each neutrophil phenotype (in %) to mild vs critical COVID-19. f Subclustering of DCs into 6 phenotypes, as indicated by the color-coded legend. g Heatmap showing DC phenotypes with corresponding marker genes and functional gene sets. h Relative contribution of each DC phenotype (in %) to COVID-19 vs non-COVID-19. i Relative contribution of each DC phenotype (in %) to mild vs critical COVID-19. j Subclustering of B-cells and plasma cells into 4 phenotypes, as indicated by the color-coded legend. k Heatmap showing B-cell and plasma cell phenotypes with corresponding marker genes and functional gene sets. l Feature plots of marker gene expression for each B-cell and plasma cell subcluster. m Violin plots showing cell cycle scores and mitochondrial gene expression by plasma cell subcluster. n B-cell receptor evenness in B-cell and plasma cell subclusters. o Relative contribution of each B-cell and plasma cell phenotype (in %) to COVID-19 vs non-COVID-19. p Relative contribution of each B-cell and plasma cell phenotype (in %) to mild vs critical COVID-19. P values were assessed by a Mann–Whitney test. *P < 0.05, **P < 0.01, ***P < 0.001.