Fig. 2: PACAP38 ligand binding site.
From: Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism
a Slice view of the PACAP38-PAC1R-Gs structure and a schematic helical sequence for PACAP38 with unresolved residues in red. b Close view of the C-terminal part of PACAP38 showing detailed interactions. c Close views of the N-terminal part of PACAP38 from two angles with 180° rotation. The effective residues in mutagenesis assay are presented by spheres. d The PAC1R-PACAP38 interaction diagrams. PACAP38 (H1-Y13) is shown as sticks. Residues are represented as spheres and colored by interaction type. Interactions between the residues and the ligand atoms are drawn as dashed lines, colored by interaction type. The solvent accessible surface of an interacting residue and of an atom are represented by haloes around the residue and the atom. The diameter of the circle is proportional to the solvent accessible surface.
