Fig. 1: AtLAS lncRNA regulation of social dominance in mice.
From: Expanding the AtLAS of non-coding RNA functions in the brain
Syn2b negatively regulates AMPAR presence in the synapses through a direct interaction with GluA1/2. The lncRNA AtLAS is an antisense to the syn2 gene and interacts with the 3′UTR of syn2b, altering the expression of syn2 isoforms through alternative polyadenylation. Mice with low AtLAS expression and reduced levels of syn2b in the mPFC exhibit stronger synapses, which leads to dominant mice.
