Fig. 4: MiDAS regions are shared across cell lines and encompass the known CFSs. | Cell Research

Fig. 4: MiDAS regions are shared across cell lines and encompass the known CFSs.

From: High-resolution mapping of mitotic DNA synthesis regions and common fragile sites in the human genome through direct sequencing

Fig. 4

a Examples of the two types of MiDAS regions present in HS68 cells. Peak heights in sigma units: PARD3B, 19.2; FHIT, 15.3; WWOX, 54.3; DIAPH2, 37.8. Bin resolution and ruler scale are as in Fig. 1b. Pk, peak. b Number of MiDAS regions of each peak type in HS68 cells. c Genome-wide average of MiDAS signal at merged- and single-peak regions in HS68 cells. Span of genomic region, 2.9 Mb. d Size distribution of MiDAS regions in U2OS, HeLa and HS68 cells as a function of peak type. e Size distribution of genes to which the MiDAS regions map. Gene sizes are plotted separately for the MiDAS regions mapping to one gene or to two adjacent genes. f, g Venn diagrams showing the overlap between the MiDAS regions identified in the three cell lines (U2OS, blue; HeLa, green; HS68, purple) and CFSs (gold).

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