Fig. 2: SIDT1 mediates the absorption of physiological miRNAs derived from natural foods. | Cell Research

Fig. 2: SIDT1 mediates the absorption of physiological miRNAs derived from natural foods.

From: SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs

Fig. 2

a, b Number of total reads (a) and reads of individual oxidized plant miRNAs (b) in livers of Sidt1+/+ or Sidt1−/− mice detected by small RNA deep sequencing. ND, not detectable. c Levels of individual dietary plant miRNAs in the serum and livers of mice (n = 8) measured by RT-qPCR. Two-tailed Student’s t-test. ****P < 0.0001. d Serum miR2911 levels in Sidt1+/+ or Sidt1–/– mice (n = 6) at the indicated time points after gavage feeding of honeysuckle decoction. Two-way ANOVA with Sidak’s post hoc test. ****P < 0.0001. e Serum miR168a level in Sidt1+/+ or Sidt1−/− mice (n = 9) at the indicated time points following rice feeding for 2 h. Two-way ANOVA with Sidak’s post hoc test. ****P < 0.0001. f–h Levels of serum miR168a (f, n = 10), liver LDLRAP1 (g, n = 5) and serum LDL cholesterol (h, n = 10) in Sidt1+/+ or Sidt1−/− mice after chow or rice feeding for 3 days. Two-way ANOVA with Sidak’s post hoc test. ns, not significant, **P < 0.01, ****P < 0.0001.

Back to article page