Fig. 4: The classification and epitope of the 10 anti-SARS-CoV-2 nAbs. | Cell Research

Fig. 4: The classification and epitope of the 10 anti-SARS-CoV-2 nAbs.

From: Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies

Fig. 4

The 10 antibodies could be classified into three groups (G1, group 1; G2, group 2; G3, group 3). Group 1 antibodies can be further divided into three subgroups (sub1, sub2, sub3). The complexes of RBD with ACE2 or nAbs are shown as cartoon with RBD colored in wheat, the light chains of nAbs colored in cyan and the heavy chains of nAbs colored in different colors. For the epitope display, RBD is shown as gray surface in top, front and back views, with interface that binds to ACE2 colored in cyan and the epitopes of different nAbs shown in respective colors. For the top views, the epitopes corresponding to heavy chains are shown in respective colors (Top view Hc) and epitopes corresponding to light chains are shown in cyan (Top view Lc). Hc, heavy chain; Lc, light chain. The “Overlapped epitopes” column displays the residue number of nAb epitope that overlaps with ACE2-binding site. The “Heavy chain” and “Light chain” columns show the residue number of the epitope of the respective chain that overlaps with ACE2-binding site. The binding affinity to RBD of IgG antibodies was also shown.

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