Fig. 5: Inhibition of iGluRs attenuated electrical conduction velocity in rat atrial myocardium. | Cell Research

Fig. 5: Inhibition of iGluRs attenuated electrical conduction velocity in rat atrial myocardium.

From: Identification of an endogenous glutamatergic transmitter system controlling excitability and conductivity of atrial cardiomyocytes

Fig. 5

a Representative right atrial ECG recordings (shown as the derivative of the electric potential as dV/dt) in anesthetic rats. The iGluR antagonists (CNQX, MK-801, and AP-5) respectively slow the electrical conduction velocity. b Pooled data of electrical conduction velocity from a. *P < 0.05, calculated by Student’s t-test or Kolmogorov–Smirnov test, n = 4−5 per group. c Typical conduction heatmap of isolated rat atria perfused with 100 μM CNQX, MK-801 or AP-5, respectively. The black arrows indicate the conduction direction of the action potential. Scale bar, 4 mm. d Pooled data of electrical conduction velocity from c. *P < 0.05, calculated by Student’s t-test, n = 7−8 per group.

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