Fig. 7: Blockage of iGluRs prevented AF. | Cell Research

Fig. 7: Blockage of iGluRs prevented AF.

From: Identification of an endogenous glutamatergic transmitter system controlling excitability and conductivity of atrial cardiomyocytes

Fig. 7

a Experimental design for analyzing the effects of the iGluR antagonists on AF. b Representative ECG and right atrial electrograms (RAE) in the heart showing that an atrial 40 Hz pacing protocol successfully induced AF in the vehicle control. However, pre-treatment with the iGluR antagonists, including CNQX, MK-801 or AP-5, prevented the occurrence of the AF under the same burst pacing stimulation. c, d Pooled data of the incidence and duration of AF induced by the 40 Hz burst pacing protocol in atria with or without the pre-treatment of the iGluR antagonists. *P < 0.05, calculated by χ2 test, n = 8−9.

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