Fig. 1: Overall structure of human telomerase holoenzyme in complex with the ssDNA substrate.
From: Zipper head mechanism of telomere synthesis by human telomerase
a, b EM density map (a) and atomic model (b) of human telomerase holoenzyme are shown in two orthogonal views. Protein and RNA subunits are color coded, and the scheme is shown below the figure. c Two orthogonal views of the overall structure of the hTR RNA. Conserved motifs are highlighted by different colors. d Secondary structure diagram of the hTR RNA. RNA elements are colored as in c. The t-PK, TWJ and H/ACA domains are denoted. Canonical Watson-Crick and non-canonical base-pairing interactions are shown as solid lines and dots, respectively.
