Fig. 4: Nup93 bridges the stems of inner and outer Y complexes in the NR subunit.
From: Cryo-EM structure of the nuclear ring from Xenopus laevis nuclear pore complex
a Nup93 bridges the stems of inner and outer Y complexes. The NR subunit contains one molecule each of Nup93 and Nup205. The extended N-terminal helix from Nup93 in subunit 1 (S1) may interact with Nup205 in the neighboring subunit (S2). b A close-up view on the interface between Nup93 and Nup205. Helix α5 of Nup93 traverses through the axial groove of the Nup205 α-solenoid. c Two close-up views on the interface between Nup93 and the vertex of inner Y complex. d A close-up view on the interface between the CTD of Nup93 and the stem of outer Y complex. e Structure alignment of Nup205 between the NR and IR subunits. Helix α5 of Nup93 remains bound to Nup205 in both cases. These two structures can be superimposed with an RMSD of ~2.8 Å over 1517 aligned Cα atoms. f Structure alignment of Nup93 and its binding partners from the NR subunit with those from the CR subunit. This alignment produces an RMSD of ~2.9 Å over 1818 aligned Cα atoms.
