Fig. 4: Inter-layer interactions in the IR monomer.
From: Near-atomic structure of the inner ring of the Saccharomyces cerevisiae nuclear pore complex
a Overall view of subunits involved in the inter-layer interactions, with eye symbols and arrowheads indicating view directions shown in the following panels. b Interactions of Nup170-1 with Nup188-1 and Nup192-1. Two interfaces are boxed by blue and yellowgreen dashed lines and enlarged in d and e, respectively. c The concave surface at the junction of Nup188-1 and Nup192-1. The area contacting Nup170-1 is circled. d, e Details of the interaction of the C-terminal region of Nup170-1 with Nup188-1 (d) and Nup192-1 (e). f Details of the interaction between Nic96-B-1 and Nup188-1. g Overall view of subunits involved in the middle and inner layer interactions. Two interfaces are boxed by black dashed lines and enlarged in i and j, respectively. h Loops connecting CCD2 and CCD3 of CNT-A-1 protrude into the groove located in the “S” domain from Nup192-1. i Long stalked CCD1 and CCD2 of CNT-A-1 clamp the N-terminal corner of Nup192-1 by extensive contacts via α-helices and loops. j Details of the interaction between Nup188-1 and CNT-B-1. k CNT-A-1 blocks the hole located between NTD and CTD of Nup192-1.
