Fig. 7: Comparison of the binding mode of the BA.2 RBD to mACE2 and hACE2. | Cell Research

Fig. 7: Comparison of the binding mode of the BA.2 RBD to mACE2 and hACE2.

From: Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins

Fig. 7

a The superposition of BA.2 RBD bound to mACE2 with BA.2 RBD bound to hACE2, with hydrogen bond or salt bridge interactions shown as dashed lines. Hydrogen bond or salt bridge interactions in hACE2-RBD and mACE2-RBD are shown as red and black dashed lines, respectively. b Residues involved in the interactions of BA.2 RBD with hACE2 and mACE2 are listed and connected by lines. Red dashed lines indicate one hydrogen bond or salt bridge and red solid lines indicate two hydrogen bonds, whereas the cyan solid line represents a π-π stacking interaction between the residues. c Infection selectivity of BA.1, BA.2, and WT strains to human, mouse, and cat.

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