Fig. 1: Overall structures of SSTR2 and SSTR4 complexes.
From: Structural insights into ligand recognition and selectivity of somatostatin receptors
a Crystal structures of SSTR2 in complex with CYN 154806 and L-054,522, respectively. SSTR2 is shown as cartoon and colored by green and protactinium separately. CYN 154806 and L-054,522 are shown as sticks and colored by yellow and violet, respectively. Disulfide bonds are shown as yellow sticks. b Cryo-EM structures of SST-14–SSTR2–Gi, SST-14–SSTR4–Gi and J-2156–SSTR4–Gi complexes. SSTR2 is shown as cartoon and colored by slate. SSTR4 is shown as cartoon and colored by pink and orange. Gαi1, Gβ, Gγ and scFv16 are colored by wheat, pale green, light blue and gray. SST-14 is shown as cartoon and colored by orange and green in SSTR2–Gi and SSTR4–Gi complexes, respectively. J-2156 is shown as sky blue sticks. c Intracellular view of structural comparison of solved structures. Red arrows indicate the movements of helices V, VI and VII.
