Fig. 4: aRBD-2-5-Fc provide prophylactic protection against WT and mouse-adapted SARS-CoV-2 in mice. | Cell Research

Fig. 4: aRBD-2-5-Fc provide prophylactic protection against WT and mouse-adapted SARS-CoV-2 in mice.

From: Hetero-bivalent nanobodies provide broad-spectrum protection against SARS-CoV-2 variants of concern including Omicron

Fig. 4

a Animal experiment scheme. b, c Body weight change (b) and survival (c) of K18-hACE2 mice treated with aRBD-2-5-Fc at a single dose of 10 mg/kg (n = 5) or PBS (n = 5) followed by i.n. infection with 2 × 104 PFU of WT SARS-CoV-2. d Body weight change of BALB/c mice treated with aRBD-2-5-Fc at doses of 1 mg/kg (n = 4), 0.1 mg/kg (n = 4) or PBS (n = 4) followed by intratracheal infection with 1 × 105 PFU of MA10. Error bars indicate means ± SD. Unpaired t-test with a Welch’s correction was used for statistical analysis of significance of the difference between the treated group and the control group, *P  ≤  0.05, **P  ≤  0.01, ***P  ≤  0.001.

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