Fig. 5: aRBD-2-5-Fc offers prophylactic and therapeutic protection against Omicron BA.1 in hamsters. | Cell Research

Fig. 5: aRBD-2-5-Fc offers prophylactic and therapeutic protection against Omicron BA.1 in hamsters.

From: Hetero-bivalent nanobodies provide broad-spectrum protection against SARS-CoV-2 variants of concern including Omicron

Fig. 5

a Animal experiment scheme. Hamsters were administered (i.p.) with aRBD-2-5-Fc at 10 mg/kg 24 h before (prophylactic group, n = 5) or 3 h after (therapeutic group, n = 5) intranasal inoculation with 1 × 104 PFU of Omicron BA.1 virus. Hamsters administered with PBS (n = 6) were set as controls. b, c Viral RNA (b) and infectious virus titers (c) in the trachea and lungs were quantified at 4 dpi. Dashed lines indicate the detection limit of the assay. Error bars indicate means ± SD. Unpaired t-test with a Welch’s correction was used for statistical analysis of significance of the difference between the treated group and the control group. NS, no significant; *P ≤ 0.05.

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