Table 2 Binding affinity KD values (nM) of Nb-Fc proteins for the tested RBDs of SARS-CoV-2 variants detected by SPR.

From: Hetero-bivalent nanobodies provide broad-spectrum protection against SARS-CoV-2 variants of concern including Omicron

SARS-CoV-2

aRBD-2-Fc

aRBD-5-Fc

aRBD-2-5-Fc

WT

1.47

2.30

0.0167

Alpha

1.20

3.21

0.0168

Beta

3.28

NB*

0.714

Gamma

4.18

NB

0.668

Delta

1.20

1.90

0.00537

Delta plus

2.88

2.15

<0.001

Kappa

1.40

NB

0.808

Lambda

1.88

NB

0.053

Omicron BA.1

7.96

NB

0.171

Omicron BA.2

7.44

NB

0.0591

  1. *NB No binding.
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