Fig. 1: The hyperdynamic interface of MITF represents a vulnerability to pharmacological dimer disruption. | Cell Research

Fig. 1: The hyperdynamic interface of MITF represents a vulnerability to pharmacological dimer disruption.

From: An exploitable Achilles heel of MITF?

Fig. 1

a–d Schematic representations of various aspects of MITF. The three locations (i.e., distinct conformations indicated in colored positions) are adjacent to Ala264 in the leucine zipper (LZ) (a). The 3-residue insertion in the LZ (b). TT-012-mediated disruption of MITF dimerization (c). TT-012 administration in vivo suppresses tumor growth and metastasis of B16F10, a MITFhi melanoma cell line (d). Figure is created with BioRender.

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