Fig. 1: Structure of the IFT-A complex.
From: Human IFT-A complex structures provide molecular insights into ciliary transport
a Domain architecture of the IFT-A subunits. The “core” and “peripheral” subcomplexes are indicated in gray boxes. WD40, TPR and Z stand for WD40, TPR-like and zinc-binding domains, respectively. * indicates that the domain is resolved at low resolution but we could use AF2 model to do rigid body docking. ** indicates that the domain is not resolved due to flexibility. b SDS-PAGE of the purified IFT-A complex. IFT139 is tagged with mCherry. c Cryo-EM density of the IFT-A complex. IFT144, IFT140, IFT139, IFT122, IFT121 and IFT43 are colored in magenta, yellow, green, orange, blue and red, respectively. The same color codes are used in the manuscript unless otherwise noted. The local refinement resolutions are indicated. d Structural model of the IFT-A complex shown as cartoons. The ZBDs are indicated by gray arrows.
