Fig. 7: Recognition of the reRNA and target DNA.
From: Discovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs
a Inset shows the location of zoomed structure in b–d. b–d reRNA recognition by REC2 (b), RuvC and RBD (c) and TID (d). e Inset shows the location of zoomed structure in f–h. f TAM recognition by the TID and REC1 domains. g In vitro cleavage of dsDNA substrates by ISFba1 TnpB RNP with wild-type (WT) or mutant ISFba1 TnpB protein. The agarose gel was visualized by EB staining. Data shown are representative of three independent experiments. h RNA–DNA heteroduplex recognition by the TID, RuvC and REC2 domains.
