Fig. 6: Gabrb2 knockout increases the susceptibility to fatal ventricular arrhythmia in mice. | Cell Research

Fig. 6: Gabrb2 knockout increases the susceptibility to fatal ventricular arrhythmia in mice.

From: A GABAergic system in atrioventricular node pacemaker cells controls electrical conduction between the atria and ventricles

Fig. 6

a–f Representative images and quantification of AVNERP. The AVNERP was evaluated by PES under different PCLs in Cre+/− mice and Gabrb2-CKO mice. The short trains of eight atrial stimuli (S1) followed by 1 extrastimulus (S2) were applied. Arrows indicate loss of S2-induced ventricular signal. Data are shown as means ± SD. P values were calculated using two-tailed unpaired student’s t-test. n = 10 mice for Cre+/− group and n = 9 mice for Gabrb2-CKO group. g, h Representative intracardiac ECG traces and quantification of the occurrence of fatal ventricular arrhythmias from Cre+/− and Gabrb2-CKO mice after the challenge of isoproterenol and high frequency atrial burst stimulation. Atrial ECG represents the ECG signals from right atrium; Lead II ECG represents the surface ECG recordings. n = 10 mice per group. P values were calculated by Fisher’s exact test. VT ventricular tachycardia, VF ventricular fibrillation, Stim stimulation.

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