Fig. 6: Heterochiral helix–helix interactions in the crystal structure of the d-19437–l-Pep-1 complex.
From: Accurate de novo design of heterochiral protein–protein interactions
a, b Heterochiral helical interfaces between l-Pep-1 and individual helix of d-19437l-Pep-1 (l-Pep-1 in green; helices of d-19437l-Pep-1 in blue. a H2 helix of d-19437l-Pep-1. b H3 helix of d-19437l-Pep-1.) c, d Helical net diagrams. Left panels, l-Pep-1. Right panels, H2 (c) and H3 (d) of d-19437l-Pep-1. Middle panels, heterochiral helix-helix interface. c Antiparallel. d Parallel. The hexagons and circles indicate the positions of Cα atoms from l-Pep-1 and d-19437l-Pep-1, respectively. The uppercase letters in hexagons and circles represent the identities of the corresponding amino acids. The lowercase letters identify the hendecad positions (abcdefghijk). Colored rectangles in dashed lines indicate the three distinct packing layers between the two heterochiral hendecad repeats. Helical net diagrams were generated by using NetWheels.64 e, f Heterochiral helix–helix packing arrangements in each of the three packing layers in c and d. e Antiparallel. f Parallel.
