Fig. 1: A brain-neuroglandular circuit regulates the intestinal microbiota and host immunity.
From: Stressing out the intestinal microbiota via a brain-neuroglandular circuit
Stress-sensitive CeA neurons promote mucus production by BGs in the duodenum via the vagus nerve. Upon activation, BGs secrete mucus to promote Lactobacillus proliferation and subsequent immune responses to enteric pathogens. Chronic stress inhibits this brain-neuroglandular circuit thereby suppressing systemic immunity to pathogen infections. Figure created with BioRender.com.
